CLINICAL TRIALS AND OBSERVATIONS Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera

نویسندگان

  • Jean-Jacques Kiladjian
  • Bruno Cassinat
  • Sylvie Chevret
  • Pascal Turlure
  • Nathalie Cambier
  • Murielle Roussel
  • Sylvia Bellucci
  • Bernard Grandchamp
  • Christine Chomienne
  • Pierre Fenaux
چکیده

1Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Service d’Hématologie Clinique and Paris 13 University, Bobigny; 2Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Unité de Biologie Cellulaire, Paris; 3Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, DBIM, Paris; 4CHU Dupuytren, Service d’Hematologie, Limoges; 5CHRU de Lille, Hopital Huriez, Service des Maladies du Sang, Lille; 6Service d’Hématologie, CHU Purpan, Toulouse; 7Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisiere, Service d’Hématologie, Paris; and 8Inserm U656 and Assistance Publique-Hôpitaux de Paris, Service de Biochimie Hormonale et Génétique, Hôpital Bichat and Paris 7 University, Paris, France

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p53 as a target in myeloproliferative neoplasms

The Philadelphia chromosome negative myeloproliferative neoplasms (MPN) originate at the level of the pluripotent hematopoietic stem cell (HSC). JAK2V617F is present in virtually all patients with polycythemia vera (PV) as well as 50-60% of patients with primary myelofibrosis (PMF) and essential thrombocythemia (ET) [1]. Recently, Nakatake and coworkers demonstrated that JAK2V617F alters p53 re...

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تاریخ انتشار 2008